Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC6669021 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhao Zibo Z Wang Lu L Bartom Elizabeth E Marshall Stacy S Rendleman Emily E Ryan Caila C Shilati Anthony A Savas Jeffrey J Chandel Navdeep N Shilatifard Ali A
Science advances 20190731 7
The zinc finger of the cerebellum (ZIC) proteins has been implicated to function in normal tissue development. Recent studies have described the critical functions of Zic proteins in cancers and the potential tumor-suppressive functions in colon cancer development and progression. To elucidate the functional roles of Zic proteins in colorectal cancer, we knocked out the Zic5 gene and analyzed the chromatin localization pattern and transcriptional regulation of target gene expression. We found th ...[more]