Dataset Information

The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank.

ABSTRACT:

Background

Depression and chronic inflammatory medical conditions have been linked to impaired cognitive ability. However despite frequent comorbidity, their combined association with cognitive ability has rarely been examined.

Methods

This study examined associations between self-reported depression and chronic inflammatory diseases and their interaction with cognitive performance in 456,748 participants of the UK Biobank, adjusting for sociodemographic and lifestyle factors. Numbers with available data ranged from 94,899 to 453,208 depending on the cognitive test.

Results

Self-reported depression was associated with poorer performance compared to controls in several cognitive tests (fully adjusted models, reaction time: B?=?6.08, 95% CI?=?5.09, 7.07; pairs matching: incidence rate ratio?=?1.02, 95% CI?=?1.02, 1.03; Trail Making Test B: B?=?1.37, 95% CI?=?0.88, 1.87; Digit Symbol Substitution Test (DSST): B = -0.35, 95% CI = -0.44, -0.27). Self-reported chronic inflammatory conditions were associated with slower reaction time (B?=?3.79, 95% CI?=?2.81, 4.78) and lower DSST scores (B = -0.21, 95% CI = -0.30, -0.13). No interaction effects were observed.

Discussion

In this large, population-based study we provide evidence of lower cognitive performance in both depression and a comprehensive category of chronic inflammatory conditions. Results are consistent with additive effects of both types of disorder on cognitive ability. Clinicians should be aware of such effects, particularly as cognitive impairment is linked to poorer disease outcomes and quality of life.

SUBMITTER: Lyall LM

PROVIDER: S-EPMC6669333 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank.

Lyall Laura M LM Cullen Breda B Lyall Donald M DM Leighton Samuel P SP Siebert Stefan S Smith Daniel J DJ Cavanagh Jonathan J

European psychiatry : the journal of the Association of European Psychiatrists 20190531

<h4>Background</h4>Depression and chronic inflammatory medical conditions have been linked to impaired cognitive ability. However despite frequent comorbidity, their combined association with cognitive ability has rarely been examined.<h4>Methods</h4>This study examined associations between self-reported depression and chronic inflammatory diseases and their interaction with cognitive performance in 456,748 participants of the UK Biobank, adjusting for sociodemographic and lifestyle factors. Num ...[more]

PMID: 31158611

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Project description:ObjectiveThe relationship between insomnia symptoms and cognitive performance is unclear, particularly at the population level. We conducted the largest examination of this association to date through analysis of the UK Biobank, a large population-based sample of adults aged 40-69 years. We also sought to determine associations between cognitive performance and self-reported chronotype, sleep medication use and sleep duration.MethodsThis cross-sectional, population-based study involved 477,529 participants, comprising 133,314 patients with frequent insomnia symptoms (age: 57.4 ± 7.7 years; 62.1% female) and 344,215 controls without insomnia symptoms (age: 56.1 ± 8.2 years; 52.0% female). Cognitive performance was assessed by a touchscreen test battery probing reasoning, basic reaction time, numeric memory, visual memory, and prospective memory. Adjusted models included relevant demographic, clinical, and sleep variables.ResultsFrequent insomnia symptoms were associated with cognitive impairment in unadjusted models; however, these effects were reversed after full adjustment, leaving those with frequent insomnia symptoms showing statistically better cognitive performance over those without. Relative to intermediate chronotype, evening chronotype was associated with superior task performance, while morning chronotype was associated with the poorest performance. Sleep medication use and both long (>9 h) and short (<7 h) sleep durations were associated with impaired performance.ConclusionsOur results suggest that after adjustment for potential confounding variables, frequent insomnia symptoms may be associated with a small statistical advantage, which is unlikely to be clinically meaningful, on simple neurocognitive tasks. Further work is required to examine the mechanistic underpinnings of an apparent evening chronotype advantage in cognitive performance and the impairment associated with morning chronotype, sleep medication use, and sleep duration extremes.

Dataset Information

The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank.

Background

Methods

Results

Discussion

Publications

The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank.

Similar Datasets

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