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Tersone A-G, New Pyridone Alkaloids from the Deep-Sea Fungus Phomopsis tersa.

ABSTRACT: Four phenylfuropyridone racemates, (±)-tersones A-C and E (1-3, 5), one phenylpyridone racemate, (±)-tersone D (4), one new pyridine alkaloid, tersone F (6), single new phenylfuropyridone, tersone G (7) and two known analogs 8 and 9 were isolated from the deep-sea fungus Phomopsis tersa. Their structures and absolute configurations were characterized on the basis of comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Moreover, compounds 1-9 were evaluated for in vitro antimicrobial and cytotoxic activity. Compounds 5b and 8b exhibited antibacterial activity against S. aureus with the MIC value of 31.5 ?g/mL, while compound 5b showed cytoxic activities against SF-268, MCF-7, HepG-2 and A549 cell lines with IC50 values of 32.0, 29.5, 39.5 and 33.2 ?M, respectively.

SUBMITTER: Chen SC

PROVIDER: S-EPMC6669727 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Tersone A-G, New Pyridone Alkaloids from the Deep-Sea Fungus Phomopsis tersa.

Chen Shan-Chong SC Liu Zhao-Ming ZM Tan Hai-Bo HB Chen Yu-Chan YC Li Sai-Ni SN Li Hao-Hua HH Guo Heng H Zhu Shuang S Liu Hong-Xin HX Zhang Wei-Min WM

Marine drugs 20190703 7

Four phenylfuropyridone racemates, (±)-tersones A-C and E (1-3, 5), one phenylpyridone racemate, (±)-tersone D (4), one new pyridine alkaloid, tersone F (6), single new phenylfuropyridone, tersone G (7) and two known analogs 8 and 9 were isolated from the deep-sea fungus Phomopsis tersa. Their structures and absolute configurations were characterized on the basis of comprehensive spectroscopic analyses, single-crystal X-ray diffracti ...[more]

PMID: 31277263

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