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Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508.

ABSTRACT: Five new benzophenone derivatives named tenellones D?H (1?5), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound 5 exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC50 values of 16.0 and 17.6 ?M, respectively.

SUBMITTER: Xu JL 

PROVIDER: S-EPMC6165036 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus <i>Phomopsis lithocarpus</i> FS508.

Xu Jian-Lin JL   Liu Hong-Xin HX   Chen Yu-Chan YC   Tan Hai-Bo HB   Guo Heng H   Xu Li-Qiong LQ   Li Sai-Ni SN   Huang Zi-Lei ZL   Li Hao-Hua HH   Gao Xiao-Xia XX   Zhang Wei-Min WM  

Marine drugs 20180911 9

Five new benzophenone derivatives named tenellones D⁻H (<b>1</b>⁻<b>5</b>), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (<b>7</b>), together with two known compounds (<b>6</b> and <b>8</b>), were isolated from the deep marine sediment-derived fungus <i>Phomopsis lithocarpus</i> FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic inte  ...[more]

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