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Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508.

ABSTRACT: Five new benzophenone derivatives named tenellones D?H (1?5), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound 5 exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC50 values of 16.0 and 17.6 ?M, respectively.

SUBMITTER: Xu JL

PROVIDER: S-EPMC6165036 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508.

Xu Jian-Lin JL Liu Hong-Xin HX Chen Yu-Chan YC Tan Hai-Bo HB Guo Heng H Xu Li-Qiong LQ Li Sai-Ni SN Huang Zi-Lei ZL Li Hao-Hua HH Gao Xiao-Xia XX Zhang Wei-Min WM

Marine drugs 20180911 9

Five new benzophenone derivatives named tenellones D⁻H (1⁻5), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic inte ...[more]

PMID: 30208615

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