Ontology highlight
ABSTRACT:
SUBMITTER: Svenningsson AL
PROVIDER: S-EPMC6671981 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20190801 1
The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-β (Aβ42/40), neuroinflammation (YKL-40), and neurodegeneration and tau pathology (T-tau and P-tau) as well as MRI measures of white-matter lesions, hippocampal volume (HV), and regional cortical thickness. We ...[more]