Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto M
PROVIDER: S-EPMC6672107 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Hashimoto Masayuki M Sun Dongming D Rittling Susan R SR Denhardt David T DT Young Wise W
The Journal of neuroscience : the official journal of the Society for Neuroscience 20070301 13
Osteopontin (OPN) is expressed in many tissues during inflammatory responses. After spinal cord injury, microglia expresses OPN at the site of injury during the early to subacute stages. However, the function of OPN in spinal cord injury is not well understood. This study examines the responses of OPN knock-out (KO) and wild-type (WT) mice to spinal cord contusion injury. KO and WT mice were injured with a modified New York University impactor. Weights of 10 or 5.6 g were dropped 6.25 mm onto th ...[more]