Ontology highlight
ABSTRACT:
SUBMITTER: Montcouquiol M
PROVIDER: S-EPMC6674235 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Montcouquiol Mireille M Sans Nathalie N Huss David D Kach Jacob J Dickman J David JD Forge Andrew A Rachel Rivka A RA Copeland Neal G NG Jenkins Nancy A NA Bogani Debora D Murdoch Jennifer J Warchol Mark E ME Wenthold Robert J RJ Kelley Matthew W MW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060501 19
Planar cell polarity (PCP) is a process in which cells develop with uniform orientation within the plane of an epithelium. To begin to elucidate the mechanisms of PCP in vertebrates, the localization of the protein Vangl2 (Van Gogh-like) was determined during the development of the mammalian cochlea. Results indicate that Vangl2 becomes asymmetrically localized to specific cell-cell boundaries along the axis of polarization and that this asymmetry is lost in PCP mutants. In addition, PDZ2 (posts ...[more]