Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
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ABSTRACT:
SUBMITTER: Vlahos A
PROVIDER: S-EPMC6675049 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
Vlahos Amanda A Mansell Toby T Saffery Richard R Novakovic Boris B
PLoS genetics 20190801 8
The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a ...[more]
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