Ontology highlight
ABSTRACT:
SUBMITTER: Meyer CT
PROVIDER: S-EPMC6675406 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Meyer Christian T CT Wooten David J DJ Paudel B Bishal BB Bauer Joshua J Hardeman Keisha N KN Westover David D Lovly Christine M CM Harris Leonard A LA Tyson Darren R DR Quaranta Vito V
Cell systems 20190220 2
Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing doses (synergistic potency) and improve outcomes by escalating effect (synergistic efficacy). Established drug synergy frameworks obscure such distinction, failing to harness the potential of modern chemical libraries. We therefore developed multi-dimensional synergy of combinations (MuSyC), a formalism based on a generalized, multi-dimensional Hill equation, which decouples synergistic potency ...[more]