Ontology highlight
ABSTRACT:
SUBMITTER: Ianevski A
PROVIDER: S-EPMC7018095 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
PLoS computational biology 20200203 2
Drug combinations are becoming a standard treatment of many complex diseases due to their capability to overcome resistance to monotherapy. In the current preclinical drug combination screening, the top combinations for further study are often selected based on synergy alone, without considering the combination efficacy and toxicity effects, even though these are critical determinants for the clinical success of a therapy. To promote the prioritization of drug combinations based on integrated an ...[more]