Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation.
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ABSTRACT:
SUBMITTER: Choi Y
PROVIDER: S-EPMC6675538 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation.
Choi Yoorim Y Yoon Dong Suk DS Lee Kyoung-Mi KM Choi Seong Mi SM Lee Myon-Hee MH Park Kwang Hwan KH Han Seung Hwan SH Lee Jin Woo JW
Aging and disease 20190801 4
Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine. However, MSCs age rapidly during long-term <i>ex vivo</i> culture and lose their therapeutic potential before they reach effective cell doses (ECD) for cell therapy. Thus, a prerequisite for effective MSC therapy is the development of cell culture methods to preserve the therapeutic potential during long-term <i>ex vivo</i> cultivation. Resveratrol (RSV) has been highlighted as a therapeutic candidate for bone ...[more]
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