Dataset Information

Measurement of relative lung perfusion with electrical impedance and positron emission tomography: an experimental comparative study in pigs.

ABSTRACT:

Background

Electrical impedance tomography (EIT) with indicator dilution may be clinically useful to measure relative lung perfusion, but there is limited information on the performance of this technique.

Methods

Thirteen pigs (50-66 kg) were anaesthetised and mechanically ventilated. Sequential changes in ventilation were made: (i) right-lung ventilation with left-lung collapse, (ii) two-lung ventilation with optimised PEEP, (iii) two-lung ventilation with zero PEEP after saline lung lavage, (iv) two-lung ventilation with maximum PEEP (20/25 cm H₂O to achieve peak airway pressure 45 cm H₂O), and (v) two-lung ventilation under unilateral pulmonary artery occlusion. Relative lung perfusion was assessed with EIT and central venous injection of saline 3%, 5%, and 10% (10 ml) during breath holds. Relative perfusion was determined by positron emission tomography (PET) using ⁶⁸Gallium-labelled microspheres. EIT and PET were compared in eight regions of equal ventro-dorsal height (right, left, ventral, mid-ventral, mid-dorsal, and dorsal), and directional changes in regional perfusion were determined.

Results

Differences between methods were relatively small (95% of values differed by less than 8.7%, 8.9%, and 9.5% for saline 10%, 5%, and 3%, respectively). Compared with PET, EIT underestimated relative perfusion in dependent, and overestimated it in non-dependent, regions. EIT and PET detected the same direction of change in relative lung perfusion in 68.9-95.9% of measurements.

Conclusions

The agreement between EIT and PET for measuring and tracking changes of relative lung perfusion was satisfactory for clinical purposes. Indicator-based EIT may prove useful for measuring pulmonary perfusion at bedside.

SUBMITTER: Bluth T

PROVIDER: S-EPMC6676171 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Measurement of relative lung perfusion with electrical impedance and positron emission tomography: an experimental comparative study in pigs.

Bluth T T Kiss T T Kircher M M Braune A A Bozsak C C Huhle R R Scharffenberg M M Herzog M M Roegner J J Herzog P P Vivona L L Millone M M Dössel O O Andreeff M M Koch T T Kotzerke J J Stender B B Gama de Abreu M M

British journal of anaesthesia 20190531 2

<h4>Background</h4>Electrical impedance tomography (EIT) with indicator dilution may be clinically useful to measure relative lung perfusion, but there is limited information on the performance of this technique.<h4>Methods</h4>Thirteen pigs (50-66 kg) were anaesthetised and mechanically ventilated. Sequential changes in ventilation were made: (i) right-lung ventilation with left-lung collapse, (ii) two-lung ventilation with optimised PEEP, (iii) two-lung ventilation with zero PEEP after saline ...[more]

PMID: 31160064

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Dataset Information

Measurement of relative lung perfusion with electrical impedance and positron emission tomography: an experimental comparative study in pigs.

Background

Methods

Results

Conclusions

Publications

Measurement of relative lung perfusion with electrical impedance and positron emission tomography: an experimental comparative study in pigs.

Similar Datasets

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