Ontology highlight
ABSTRACT:
SUBMITTER: Cho ME
PROVIDER: S-EPMC6677391 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cho Monique E ME Branton Mary H MH Smith David A DA Bartlett Linda L Howard Lilian L Reynolds James C JC Rosenstein Donald D Sethi Sanjeev S Nava M Berenice MB Barisoni Laura L Fervenza Fernando C FC Kopp Jeffrey B JB
American journal of nephrology 20190409 5
<h4>Background</h4>In adults with primary focal segmental glomerulosclerosis (FSGS), daily prednisone may induce complete remissions (CR) and partial remissions (PR), but relapses are frequent and adverse events are common.<h4>Methods</h4>We carried out 2 open-label, uncontrolled trials to explore the efficacy and tolerability of pulse oral dexamethasone as an alternative to daily prednisone. We enrolled adult patients with proteinuria > 3.5 g/day despite the use of renin-angiotensin-aldosterone ...[more]