Ontology highlight
ABSTRACT:
SUBMITTER: Abdel-Gadir A
PROVIDER: S-EPMC6677395 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Abdel-Gadir Azza A Stephen-Victor Emmanuel E Gerber Georg K GK Noval Rivas Magali M Wang Sen S Harb Hani H Wang Leighanne L Li Ning N Crestani Elena E Spielman Sara S Secor William W Biehl Heather H DiBenedetto Nicholas N Dong Xiaoxi X Umetsu Dale T DT Bry Lynn L Rachid Rima R Chatila Talal A TA
Nature medicine 20190624 7
The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice. Infants and mice with FA had decreased IgA and increased IgE binding to fecal bacteria, indicative of a broader breakdown of oral tolerance than hitherto appreciated. Therapy with Clostridiales species impacted by dysbiosis, either as a consortium or as monotherapy with Subdoligranulum variabile, suppressed ...[more]