Ontology highlight
ABSTRACT:
SUBMITTER: Fakira AK
PROVIDER: S-EPMC6677605 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Fakira Amanda K AK Peck Emily G EG Liu Yutong Y Lueptow Lindsay M LM Trimbake Nikita A NA Han Ming-Hu MH Calipari Erin S ES Devi Lakshmi A LA
Neuropharmacology 20190612
GPR83, the receptor for the neuropeptide PEN, exhibits high expression in the nucleus accumbens of the human and rodent brain, suggesting that it plays a role in modulating the mesolimbic reward pathway. However, the cell-type specific expression of GPR83, its functional impact in the reward pathway, and in drug reward-learning has not been fully explored. Using GPR83/eGFP mice, we show high GPR83 expression on cholinergic interneurons in the nucleus accumbens and moderate expression on ventral ...[more]