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Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience.

ABSTRACT: Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

SUBMITTER: Rossoff J 

PROVIDER: S-EPMC6677669 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience.

Rossoff Jenna J   Chaudhury Sonali S   Soneji Maulin M   Patel Sameer J SJ   Kwon Soyang S   Armstrong Amy A   Muller William J WJ  

Open forum infectious diseases 20190801 8

Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity. ...[more]

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