Unknown

Dataset Information

0

Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements.


ABSTRACT: Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65-81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer's GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1 + T2-FLAIR cortical thickness data. These analyses demonstrated that T1 + T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x2, p < 0.05) and demonstrated significantly thicker cortical thickness means (p < 0.05) with medium to large effect sizes. Significant regions of age-related cortical atrophy were identified within the T1 + T2-FLAIR data (FDR corrected, p < 0.05). This is in contrast to the T1-only data where no regions survived FDR correction. In summary, T1 + T2-FLAIR data were associated with significant improvement in cortical segmentation and the identification of age-related cortical atrophy. Future studies should consider employing this imaging strategy to obtain cortical thickness measurements sensitive to age-related changes.

SUBMITTER: Lindroth H 

PROVIDER: S-EPMC6677836 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements.

Lindroth Heidi H   Nair Veena A VA   Stanfield Casandra C   Casey Cameron C   Mohanty Rosaleena R   Wayer Daniel D   Rowley Paul P   Brown Roger R   Prabhakaran Vivek V   Sanders Robert D RD  

Scientific reports 20190802 1


Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65-81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were p  ...[more]

Similar Datasets

| S-EPMC4926954 | biostudies-literature
| S-EPMC10407290 | biostudies-literature
| S-EPMC7816007 | biostudies-literature
| S-EPMC7122737 | biostudies-literature
| S-EPMC7490581 | biostudies-literature
| S-EPMC5845848 | biostudies-literature
| S-EPMC8115360 | biostudies-literature
| S-EPMC4205107 | biostudies-literature
| S-EPMC5496213 | biostudies-literature
| S-EPMC8252099 | biostudies-literature