Ontology highlight
ABSTRACT:
SUBMITTER: Freitas J
PROVIDER: S-EPMC6678255 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Freitas Jaime J Santos Susana Gomes SG Gonçalves Raquel Madeira RM Teixeira José Henrique JH Barbosa Mário Adolfo MA Almeida Maria Inês MI
International journal of molecular sciences 20190712 14
The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone regeneration. Their beneficial effects can be improved by modulating the expression levels of sp ...[more]