Ontology highlight
ABSTRACT:
SUBMITTER: Rosso V
PROVIDER: S-EPMC6678378 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Rosso Valentina V Panuzzo Cristina C Petiti Jessica J Carturan Sonia S Dragani Matteo M Andreani Giacomo G Fava Carmen C Saglio Giuseppe G Bracco Enrico E Cilloni Daniela D
Journal of clinical medicine 20190704 7
In most of the acute myeloid leukemia patients there is an aberrant tyrosine kinase activity. The prototype of Sprouty proteins was originally identified in <i>Drosophila melanogaster</i> as antagonists of Breathless, the mammalian ortholog of fibroblast growth factor receptor. Usually, SPRY family members are inhibitors of RAS signaling induced by tyrosine kinases receptors and they are implicated in negative feedback processes regulating several intracellular pathways. The present study aims t ...[more]