Ontology highlight
ABSTRACT:
SUBMITTER: Currie JD
PROVIDER: S-EPMC6679413 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Currie Joshua D JD Grosser Lidia L Murawala Prayag P Schuez Maritta M Michel Martin M Tanaka Elly M EM Sandoval-Guzmán Tatiana T
Biology open 20190718 7
The heterogeneous properties of dermal cell populations have been posited to contribute toward fibrotic, imperfect wound healing in mammals. Here we characterize an adult population of dermal fibroblasts that maintain an active <i>Prrx1</i> enhancer which originally marked mesenchymal limb progenitors. In contrast to their abundance in limb development, postnatal <i>Prrx1</i> enhancer-positive cells (Prrx1<sup>enh+</sup>) make up a small subset of adult dermal cells (∼0.2%) and reside mainly wit ...[more]