Ontology highlight
ABSTRACT:
SUBMITTER: Bauereiss A
PROVIDER: S-EPMC6680167 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Traffic (Copenhagen, Denmark) 20150414 6
Amyloid-β (Aβ)-peptide, the major constituent of the plaques that develop during Alzheimer's disease, is generated via the cleavage of Aβ precursor protein (APP) by β-site APP-cleaving enzyme (BACE). Using live-cell imaging of APP and BACE labeled with pH-sensitive proteins, we could detect the release events of APP and BACE and their distinct kinetics. We provide kinetic evidence for the cleavage of APP by α-secretase on the cellular surface after exocytosis. Furthermore, simultaneous dual-colo ...[more]