Unknown

Dataset Information

0

QT prolongation predicts short-term mortality independent of comorbidity.


ABSTRACT:

Aims

A prolonged corrected QT interval (QTc) ?500?ms is associated with high all-cause mortality in hospitalized patients. We aimed to explore any difference in short- and long-term mortality in patients with QTc ?500?ms compared with patients with QTc <500?ms after adjustment for comorbidity and main diagnosis.

Methods and results

Patients with QTc ?500?ms who were hospitalized at Telemark Hospital Trust, Norway between January 2007 and April 2014 were identified. Thirty-day and 3-year all-cause mortality in 980 patients with QTc ?500?ms were compared with 980 patients with QTc <500?ms, matched for age and sex and adjusting for Charlson comorbidity index (CCI), previous admissions, and main diagnoses. QTc ?500?ms was associated with increased 30-day all-cause mortality [hazard ratio (HR) 1.90, 95% confidence interval (CI) 1.38-2.62; P?ConclusionQTc ?500?ms is a powerful predictor of short-term mortality overruling comorbidities. QTc ?500?ms also predicted long-term mortality, but this effect was mainly caused by the increased short-term mortality. For long-term mortality, comorbidity was more important.

SUBMITTER: Gibbs C 

PROVIDER: S-EPMC6680365 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

QT prolongation predicts short-term mortality independent of comorbidity.

Gibbs Charlotte C   Thalamus Jacob J   Kristoffersen Doris Tove DT   Svendsen Martin Veel MV   Holla Øystein L ØL   Heldal Kristian K   Haugaa Kristina H KH   Hysing Jan J  

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20190801 8


<h4>Aims</h4>A prolonged corrected QT interval (QTc) ≥500 ms is associated with high all-cause mortality in hospitalized patients. We aimed to explore any difference in short- and long-term mortality in patients with QTc ≥500 ms compared with patients with QTc <500 ms after adjustment for comorbidity and main diagnosis.<h4>Methods and results</h4>Patients with QTc ≥500 ms who were hospitalized at Telemark Hospital Trust, Norway between January 2007 and April 2014 were identified. Thirty-day and  ...[more]

Similar Datasets

| S-EPMC4698188 | biostudies-literature
| S-EPMC4239140 | biostudies-other
| S-EPMC6761551 | biostudies-literature
| S-EPMC4901860 | biostudies-other
| S-EPMC1767957 | biostudies-literature
| S-EPMC2897792 | biostudies-literature
| S-EPMC9223350 | biostudies-literature
| S-EPMC3579250 | biostudies-literature
| S-EPMC6931613 | biostudies-literature
| S-EPMC7995001 | biostudies-literature