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ABSTRACT: Aims
A prolonged corrected QT interval (QTc) ?500?ms is associated with high all-cause mortality in hospitalized patients. We aimed to explore any difference in short- and long-term mortality in patients with QTc ?500?ms compared with patients with QTc <500?ms after adjustment for comorbidity and main diagnosis.Methods and results
Patients with QTc ?500?ms who were hospitalized at Telemark Hospital Trust, Norway between January 2007 and April 2014 were identified. Thirty-day and 3-year all-cause mortality in 980 patients with QTc ?500?ms were compared with 980 patients with QTc <500?ms, matched for age and sex and adjusting for Charlson comorbidity index (CCI), previous admissions, and main diagnoses. QTc ?500?ms was associated with increased 30-day all-cause mortality [hazard ratio (HR) 1.90, 95% confidence interval (CI) 1.38-2.62; P?ConclusionQTc ?500?ms is a powerful predictor of short-term mortality overruling comorbidities. QTc ?500?ms also predicted long-term mortality, but this effect was mainly caused by the increased short-term mortality. For long-term mortality, comorbidity was more important.
SUBMITTER: Gibbs C
PROVIDER: S-EPMC6680365 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Gibbs Charlotte C Thalamus Jacob J Kristoffersen Doris Tove DT Svendsen Martin Veel MV Holla Øystein L ØL Heldal Kristian K Haugaa Kristina H KH Hysing Jan J
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20190801 8
<h4>Aims</h4>A prolonged corrected QT interval (QTc) ≥500 ms is associated with high all-cause mortality in hospitalized patients. We aimed to explore any difference in short- and long-term mortality in patients with QTc ≥500 ms compared with patients with QTc <500 ms after adjustment for comorbidity and main diagnosis.<h4>Methods and results</h4>Patients with QTc ≥500 ms who were hospitalized at Telemark Hospital Trust, Norway between January 2007 and April 2014 were identified. Thirty-day and ...[more]