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Colloidal Behavior of Cellulose Nanocrystals Grafted with Poly(2-alkyl-2-oxazoline)s.

ABSTRACT: Polymer grafting onto cellulose nanocrystals (CNCs) has been used as a tool to improve CNC dispersion in nonpolar solvents or polymeric matrixes. The grafting of flexible polymer chains onto rigid particle surfaces leads to significant modifications in colloidal behavior. Here, poly(2-alkyl-2-oxazoline)s of well-defined molar mass and narrow molar mass distribution were synthesized by cationic ring-opening polymerization and grafted onto CNC surfaces, where the coupling reaction was favored when partially hydrolyzed polymers were used (reaching 64% reaction yield). The particles grafted with polymer chains could be redispersed in water after freeze-drying, producing stable dispersions, and they were not cell-toxic up to 10 wt % aqueous dispersion. Colloidal stability, nanostructure organization, and rheological behavior of grafted CNC and CNC-grafted CNC mixtures were evaluated. The rheological behavior of grafted nanoparticles, meanwhile, showed new features when compared to original CNC dispersions. Aqueous CNC dispersions showed a liquid crystal nematic organization and rheological behavior characteristic of true gel (at 5 wt %) prior to drying. On the other hand, nanoparticle dispersions behaved as weak gels upon the addition of 10 wt % of CNC-g-(PEtOx95-s-Ei5) under the same conditions. Dispersions of CNC-g-P(PEtOx-s-Ei) particles obtained by redispersion of freeze-dried particles behaved as a fluid, without the presence of the nematic organization. Through oscillatory rheology and time-domain NMR results, it can be concluded that polymer-water interactions are dominant over CNC-water interactions, being responsible for CNC nematic phase disruption. By introducing polymer chains, the introduction of isotropic character modifies water organization, changing the flow behavior of CNC-grafted with poly(oxazoline)s.

SUBMITTER: Gauche C

PROVIDER: S-EPMC6682102 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Colloidal Behavior of Cellulose Nanocrystals Grafted with Poly(2-alkyl-2-oxazoline)s.

Gauche Cony C Felisberti Maria Isabel MI

ACS omega 20190709 7

Polymer grafting onto cellulose nanocrystals (CNCs) has been used as a tool to improve CNC dispersion in nonpolar solvents or polymeric matrixes. The grafting of flexible polymer chains onto rigid particle surfaces leads to significant modifications in colloidal behavior. Here, poly(2-alkyl-2-oxazoline)s of well-defined molar mass and narrow molar mass distribution were synthesized by cationic ring-opening polymerization and grafted onto CNC surfaces, where the coupling reaction was favored when ...[more]

PMID: 31460300

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Project description:Bone tissue defects resulting from periodontal disease are often treated using guided tissue regeneration (GTR). The barrier membranes utilized here should prevent soft tissue infiltration into the bony defect and simultaneously support bone regeneration. In this study, we designed a degradable poly(l-lactide-co-glycolide) (PLGA) membrane that was surface-modified with cell adhesive arginine-glycine-aspartic acid (RGD) motifs. For a novel method of membrane manufacture, the RGD motifs were coupled with the non-ionic amphiphilic polymer poly(2-oxazoline) (POx). The RGD-containing membranes were then prepared by solvent casting of PLGA, POx coupled with RGD (POx_RGD), and poly(ethylene glycol) (PEG) solution in methylene chloride (DCM), followed by DCM evaporation and PEG leaching. Successful coupling of RGD to POx was confirmed spectroscopically by Raman, Fourier transform infrared in attenuated reflection mode (FTIR-ATR), and X-ray photoelectron (XPS) spectroscopy, while successful immobilization of POx_RGD on the membrane surface was confirmed by XPS and FTIR-ATR. The resulting membranes had an asymmetric microstructure, as shown by scanning electron microscopy (SEM), where the glass-cured surface was more porous and had a higher surface area then the air-cured surface. The higher porosity should support bone tissue regeneration, while the air-cured side is more suited to preventing soft tissue infiltration. The behavior of osteoblast-like cells on PLGA membranes modified with POx_RGD was compared to cell behavior on PLGA foil, non-modified PLGA membranes, or PLGA membranes modified only with POx. For this, MG-63 cells were cultured for 4, 24, and 96 h on the membranes and analyzed by metabolic activity tests, live/dead staining, and fluorescent staining of actin fibers. The results showed bone cell adhesion, proliferation, and viability to be the highest on membranes modified with POx_RGD, making them possible candidates for GTR applications in periodontology and in bone tissue engineering.

Dataset Information

Colloidal Behavior of Cellulose Nanocrystals Grafted with Poly(2-alkyl-2-oxazoline)s.

Publications

Colloidal Behavior of Cellulose Nanocrystals Grafted with Poly(2-alkyl-2-oxazoline)s.

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