Ontology highlight
ABSTRACT:
SUBMITTER: Witzigmann D
PROVIDER: S-EPMC6682401 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Witzigmann Dominik D Uhl Philipp P Sieber Sandro S Kaufman Christina C Einfalt Tomaz T Schöneweis Katrin K Grossen Philip P Buck Jonas J Ni Yi Y Schenk Susanne H SH Hussner Janine J Meyer Zu Schwabedissen Henriette E HE Québatte Gabriela G Mier Walter W Urban Stephan S Huwyler Jörg J
eLife 20190723
Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target the sodium-taurocholate cotransporting polypeptide (NTCP; <i>SLC10A1</i>) on the sinusoidal membrane of hepatocytes. Physicochemical properties of targeted nanoparticles were optimized and NTCP-specific ...[more]