Dataset Information

Predicting Bipolar Disorder Risk Factors in Distressed Young Adults From Patterns of Brain Activation to Reward: A Machine Learning Approach.

ABSTRACT:

Background

The aim of this study was to apply multivariate pattern recognition to predict the severity of behavioral traits and symptoms associated with risk for bipolar spectrum disorder from patterns of whole-brain activation during reward expectancy to facilitate the identification of individual-level neural biomarkers of bipolar disorder risk.

Methods

We acquired functional neuroimaging data from two independent samples of transdiagnostically recruited adults (18-25 years of age; n = 56, mean age 21.9 ± 2.2 years, 42 women; n = 36, mean age 21.2 ± 2.2 years, 24 women) during reward expectancy task performance. Pattern recognition model performance in each sample was measured using correlation and mean squared error between actual and whole-brain activation-predicted scores on behavioral traits and symptoms.

Results

In the first sample, the model significantly predicted severity of a specific hypo/mania-related symptom, heightened energy, measured by the energy manic subdomain of the Mood Spectrum Structured Interviews (r = .42, p = .001; mean squared error = 9.93, p = .001). The region with the highest contribution to the model was the left ventrolateral prefrontal cortex. Results were confirmed in the second sample (r = .33, p = .01; mean squared error = 8.61, p = .01), in which the severity of this symptom was predicted using a bilateral ventrolateral prefrontal cortical mask (r = .33, p = .009, mean squared error = 9.37, p = .04).

Conclusions

The severity of a specific hypo/mania-related symptom was predicted from patterns of whole-brain activation in two independent samples. Given that emerging manic symptoms predispose to bipolar disorders, these findings could provide neural biomarkers to aid early identification of individual-level bipolar disorder risk in young adults.

SUBMITTER: de Oliveira L

PROVIDER: S-EPMC6682607 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Predicting Bipolar Disorder Risk Factors in Distressed Young Adults From Patterns of Brain Activation to Reward: A Machine Learning Approach.

de Oliveira Leticia L Portugal Liana C L LCL Pereira Mirtes M Chase Henry W HW Bertocci Michele M Stiffler Richelle R Greenberg Tsafrir T Bebko Genna G Lockovich Jeanette J Aslam Haris H Mourao-Miranda Janaina J Phillips Mary L ML

Biological psychiatry. Cognitive neuroscience and neuroimaging 20190417 8

<h4>Background</h4>The aim of this study was to apply multivariate pattern recognition to predict the severity of behavioral traits and symptoms associated with risk for bipolar spectrum disorder from patterns of whole-brain activation during reward expectancy to facilitate the identification of individual-level neural biomarkers of bipolar disorder risk.<h4>Methods</h4>We acquired functional neuroimaging data from two independent samples of transdiagnostically recruited adults (18-25 years of a ...[more]

PMID: 31201147

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Dataset Information

Predicting Bipolar Disorder Risk Factors in Distressed Young Adults From Patterns of Brain Activation to Reward: A Machine Learning Approach.

Background

Methods

Results

Conclusions

Publications

Predicting Bipolar Disorder Risk Factors in Distressed Young Adults From Patterns of Brain Activation to Reward: A Machine Learning Approach.

Similar Datasets

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