Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC6683746 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kumar Abhishek A Shutova Maria S MS Tanaka Keiichiro K Iwamoto Daniel V DV Calderwood David A DA Svitkina Tatyana M TM Schwartz Martin A MA
The Journal of cell biology 20190717 8
Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using a fluorescence-based talin tension sensor (TS), we found that uniaxial stretch of cells on elastic substrates increased tension on talin, which was unexpectedly independent of the orientation of the focal ...[more]