Ontology highlight
ABSTRACT:
SUBMITTER: Zeleznjak J
PROVIDER: S-EPMC6683999 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Železnjak Jelena J Lisnić Vanda Juranić VJ Popović Branka B Lisnić Berislav B Babić Marina M Halenius Anne A L'Hernault Anne A Roviš Tihana Lenac TL Hengel Hartmut H Erhard Florian F Redwood Alec J AJ Vidal Silvia M SM Dölken Lars L Krmpotić Astrid A Jonjić Stipan S
The Journal of experimental medicine 20190529 8
CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However, the lack of MHC I on the cell surface renders the infected cell susceptible to NK cell killing upon missing self recognition. To counter this, mouse CMV (MCMV) rescues some MHC I molecules to engage inhibitory Ly49 receptors. Here we identify a new viral protein, MATp1, that is essential for MHC I surface rescue. Rescued altered-self MHC I molecules show increased affinity to inhibitory Ly49 receptors, re ...[more]