Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system.
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ABSTRACT:
SUBMITTER: Rizzo MD
PROVIDER: S-EPMC6684287 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system.
Rizzo Michael D MD Crawford Robert B RB Bach Anthony A Sermet Sera S Amalfitano Andrea A Kaminski Norbert E NE
Journal of neuroimmunology 20190520
Toll-like receptor 7 (TLR7)-activation has been implicated as a significant mechanism of neuroinflammation triggered by ssRNA viruses. Infiltration of monocytes into the brain and astrocyte activation occurs during in vivo TLR7-mediated neuroinflammation. The objective here was to determine whether the TLR7 agonist, imiquimod, and interferon-alpha (IFN-α), promote monocyte-mediated astrocyte secretion of pro-inflammatory factors. Using a human primary co-culture system, we demonstrate that monoc ...[more]
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