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ABSTRACT: Background and purpose
AV-1451 (18 F-AV-1451, flortaucipir) positron emission tomography was performed in C9orf72 expansion carriers to assess tau accumulation and disease manifestation.Methods
Nine clinically characterized C9orf72 expansion carriers and 18 age- and gender- matched cognitively normal individuals were psychometrically evaluated and underwent tau positron emission tomography imaging. The regional AV-1451 standard uptake value ratios from multiple brain regions were analyzed. Spearman correlation was performed to relate the AV-1451 standard uptake value ratio to clinical, psychometric and cerebrospinal fluid measures.Results
C9orf72 expansion carriers had increased AV-1451 binding in the entorhinal cortex compared to controls. Primary age-related tauopathy was observed postmortem in one patient. AV-1451 uptake did not correlate with clinical severity, disease duration, psychometric performance or cerebrospinal fluid markers.Conclusion
C9orf72 expansion carriers exhibited increased AV-1451 uptake in entorhinal cortex compared to cognitively normal controls, suggesting a propensity for primary age-related tauopathy. However, AV-1451 accumulation was not associated with psychometric performance in our cohort.
SUBMITTER: Ly CV
PROVIDER: S-EPMC6684398 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ly C V CV Koenig L L Christensen J J Gordon B B Beaumont H H Dahiya S S Chen J J Su Y Y Nelson B B Jockel-Balsarotti J J Drain C C Jerome G G Morris J C JC Fagan A M AM Harms M B MB Benzinger T L S TLS Miller T M TM Ances B M BM
European journal of neurology 20190325 9
<h4>Background and purpose</h4>AV-1451 (<sup>18</sup> F-AV-1451, flortaucipir) positron emission tomography was performed in C9orf72 expansion carriers to assess tau accumulation and disease manifestation.<h4>Methods</h4>Nine clinically characterized C9orf72 expansion carriers and 18 age- and gender- matched cognitively normal individuals were psychometrically evaluated and underwent tau positron emission tomography imaging. The regional AV-1451 standard uptake value ratios from multiple brain r ...[more]