Tau-positron emission tomography correlates with neuropathology findings.
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ABSTRACT: Introduction
Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.Methods
Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.Results
Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02).Discussion
Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.
SUBMITTER: Lowe VJ
PROVIDER: S-EPMC7067654 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Tau-positron emission tomography correlates with neuropathology findings.
Lowe Val J VJ Lundt Emily S ES Albertson Sabrina M SM Min Hoon-Ki HK Fang Ping P Przybelski Scott A SA Senjem Matthew L ML Schwarz Christopher G CG Kantarci Kejal K Boeve Bradley B Jones David T DT Reichard R Ross RR Tranovich Jessica F JF Hanna Al-Shaikh Fadi S FS Knopman David S DS Jack Clifford R CR Dickson Dennis W DW Petersen Ronald C RC Murray Melissa E ME
Alzheimer's & dementia : the journal of the Alzheimer's Association 20200104 3
<h4>Introduction</h4>Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings.<h4>Methods</h4>Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal.<h4>Results</h4>Participants with Braak stages of IV ...[more]
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2011-11-01 | GSE21217 | GEO
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