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A personalized approach to acute myeloid leukemia therapy: current options.

ABSTRACT: Therapeutic options for acute myeloid leukemia (AML) have remained unchanged for nearly the past 5 decades, with cytarabine and anthracyclines and use of hypomethylating agents for less intensive therapy. Implementation of large-scale genomic studies in the past decade has unraveled the genetic landscape and molecular etiology of AML. The approval of several novel drugs for targeted therapy, including midostaurin, enasidenib, ivosidenib, gemtuzumab-ozogamicin, and CPX351 by the US Food and Drug Administration has widened the treatment options for clinicians treating AML. This review focuses on some of these novel therapies and other promising agents under development, along with key clinical trial findings in AML.

SUBMITTER: Illangeswaran RSS

PROVIDER: S-EPMC6684879 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A personalized approach to acute myeloid leukemia therapy: current options.

Illangeswaran Raveen Stephen Stallon RSS Das Saswati S Paul Daniel Zechariah DZ Mathews Vikram V Balasubramanian Poonkuzhali P

Pharmacogenomics and personalized medicine 20190802

Therapeutic options for acute myeloid leukemia (AML) have remained unchanged for nearly the past 5 decades, with cytarabine and anthracyclines and use of hypomethylating agents for less intensive therapy. Implementation of large-scale genomic studies in the past decade has unraveled the genetic landscape and molecular etiology of AML. The approval of several novel drugs for targeted therapy, including midostaurin, enasidenib, ivosidenib, gemtuzumab-ozogamicin, and CPX351 by the US Food and Drug ...[more]

PMID: 31447578

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