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Acute myeloid leukemia in the elderly: therapeutic options and choice.

ABSTRACT: Acute myeloid leukemia (AML) therapies are rapidly evolving with novel targeted therapies showing high-level responses in a notoriously difficult to treat group of patients - the elderly and unfit. This review will examine the outcomes of older AML patients (>60 years old) with conventional induction strategies, and published literature on risks of pursuit of induction. Low-intensity combination therapy response rates appear to be approaching that of induction regimens, and with lower toxicity, low-intensity therapy likely represents the future standard approach in this age group. Lastly, allogeneic transplant appears to have a role in increasing durable remissions regardless of age and should be considered in patients with limited comorbidities.

SUBMITTER: Webster JA

PROVIDER: S-EPMC7147978 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Acute myeloid leukemia in the elderly: therapeutic options and choice.

Webster Jonathan A JA Pratz Keith W KW

Leukemia & lymphoma 20170602 2

Acute myeloid leukemia (AML) therapies are rapidly evolving with novel targeted therapies showing high-level responses in a notoriously difficult to treat group of patients - the elderly and unfit. This review will examine the outcomes of older AML patients (>60 years old) with conventional induction strategies, and published literature on risks of pursuit of induction. Low-intensity combination therapy response rates appear to be approaching that of induction regimens, and with lower toxicity, ...[more]

PMID: 28573892

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