Ontology highlight
ABSTRACT:
SUBMITTER: Grillova L
PROVIDER: S-EPMC6685089 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Grillová Linda L Oppelt Jan J Mikalová Lenka L Nováková Markéta M Giacani Lorenzo L Niesnerová Anežka A Noda Angel A AA Mechaly Ariel E AE Pospíšilová Petra P Čejková Darina D Grange Philippe A PA Dupin Nicolas N Strnadel Radim R Chen Marcus M Denham Ian I Arora Natasha N Picardeau Mathieu M Weston Christopher C Forsyth R Allyn RA Šmajs David D
Frontiers in microbiology 20190731
Syphilis, caused by <i>Treponema pallidum</i> subsp. <i>pallidum</i> (TPA), remains an important public health problem with an increasing worldwide prevalence. Despite recent advances in <i>in vitro</i> cultivation, genetic variability of this pathogen during infection is poorly understood. Here, we present contemporary and geographically diverse complete treponemal genome sequences isolated directly from patients using a methyl-directed enrichment prior to sequencing. This approach reveals that ...[more]