Ontology highlight
ABSTRACT:
SUBMITTER: Drashansky TT
PROVIDER: S-EPMC6685710 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Drashansky Theodore T TT Helm Eric E Huo Zhiguang Z Curkovic Nina N Kumar Preet P Luo Xiaoping X Parthasarathy Upasana U Zuniga Ashley A Cho Jonathan J JJ Lorentsen Kyle J KJ Xu Zhiwei Z Uddin Mohammad M Moshkani Safiehkhathoon S Zhou Liang L Avram Dorina D
Science advances 20190807 8
Regulatory T (T<sub>reg</sub>) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the T<sub>reg</sub> cell program. We found that mice deficient in Bcl11b TF solely in T<sub>reg</sub> cells developed fatal autoimmunity, and Bcl11b-deficient T<sub>reg</sub> cells had severely altered function. Bcl11b KO T<sub>reg</sub> cells showed decreased functional marker levels in homeostatic condi ...[more]