Ontology highlight
ABSTRACT:
SUBMITTER: Cabello-Kindelan C
PROVIDER: S-EPMC6971488 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Diabetes 20191111 2
Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (T<sub>regs</sub>) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded T<sub>regs</sub> in T1D and solid-organ transplant recipients are limited by poor T<sub>reg</sub> engraftment without host manipulation. We showed that T<sub>reg</sub> engraftment and ...[more]