Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC6686201 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Yang Xinyuan X Shen He H Buckley Brian B Chen Yanmin Y Yang Nuo N Mussell Ashley L AL Chernov Mikhail M Kobzik Lester L Frangou Costa C Han Su-Xia SX Zhang Jianmin J
Oncogene 20181212 15
Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is controlled by pathway crosstalks in tumourigenesis remains poorly understood. Here, we performed a targeted kinase inhibitor screen in human cancer cells to identify novel Hippo pathway regulators. Notably, we identified the nerve growth factor (NGF) receptor tyrosine kinase (NTRK1), a molecule ...[more]