Ontology highlight
ABSTRACT:
SUBMITTER: Phelan MA
PROVIDER: S-EPMC6686703 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Phelan Michael A MA Gianforcaro Anthony L AL Gerstenhaber Jonathan A JA Lelkes Peter I PI
Tissue engineering. Part C, Methods 20190801 8
<h4>Impact statement</h4>The rotating wall vessel (RWV) bioreactor is a powerful tool for the generation of sizeable, faster-growing organoids. However, the ideal, low-shear, modeled microgravity environment in the RWV is frequently disrupted by the formation of bubbles, a critical but understated failure mode. To address this, we have designed and fabricated a novel, modified RWV bioreactor capable of continuously removing bubbles while providing optimal fluid dynamics. We validated the capacit ...[more]