Dataset Information

Hippocampal Shape Maturation in Childhood and Adolescence.

ABSTRACT: The hippocampus is a subcortical structure critical for learning and memory, and a thorough understanding of its neurodevelopment is important for studying these processes in health and disease. However, few studies have quantified the typical developmental trajectory of the structure in childhood and adolescence. This study examined the cross-sectional age-related changes and sex differences in hippocampal shape in a multisite, multistudy cohort of 1676 typically developing children (age 1-22 years) using a novel intrinsic brain mapping method based on Laplace-Beltrami embedding of surfaces. Significant age-related expansion was observed bilaterally and nonlinear growth was observed primarily in the right head and tail of the hippocampus. Sex differences were also observed bilaterally along the lateral and medial aspects of the surface, with females exhibiting relatively larger surface expansion than males. Additionally, the superior posterior lateral surface of the left hippocampus exhibited an age-sex interaction with females expanding faster than males. Shape analysis provides enhanced sensitivity to regional changes in hippocampal morphology over traditional volumetric approaches and allows for the localization of developmental effects. Our results further support evidence that hippocampal structures follow distinct maturational trajectories that may coincide with the development of learning and memory skills during critical periods of development.

SUBMITTER: Lynch KM

PROVIDER: S-EPMC6686754 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Hippocampal Shape Maturation in Childhood and Adolescence.

Lynch Kirsten M KM Shi Yonggang Y Toga Arthur W AW Clark Kristi A KA

Cerebral cortex (New York, N.Y. : 1991) 20190801 9

The hippocampus is a subcortical structure critical for learning and memory, and a thorough understanding of its neurodevelopment is important for studying these processes in health and disease. However, few studies have quantified the typical developmental trajectory of the structure in childhood and adolescence. This study examined the cross-sectional age-related changes and sex differences in hippocampal shape in a multisite, multistudy cohort of 1676 typically developing children (age 1-22 y ...[more]

PMID: 30272143

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Project description:ImportanceThe trajectory of cortical gray matter development in childhood has been characterized by early neurogenesis and volume increase, peaking at puberty followed by selective elimination and myelination, resulting in volume loss and thinning. This inverted U-shaped trajectory, as well as cortical thickness, has been associated with cognitive and emotional function. Synaptic pruning-based volume decline has been related to experience-dependent plasticity in animals. To date, there have been no data to inform whether and how childhood depression might be associated with this trajectory.ObjectiveTo examine the effects of early childhood depression, from the preschool age to the school age period, on cortical gray matter development measured across 3 waves of neuroimaging from late school age to early adolescence.Design, setting, and participantsData were collected in an academic research setting from September 22, 2003, to December 13, 2014, on 193 children aged 3 to 6 years from the St Louis, Missouri, metropolitan area who were observed for up to 11 years in a longitudinal behavioral and neuroimaging study of childhood depression. Multilevel modeling was applied to explore the association between the number of childhood depression symptoms and prior diagnosis of major depressive disorder and the trajectory of gray matter change across 3 scan waves. Data analysis was conducted from October 29, 2014, to September 28, 2015.Main outcomes and measuresVolume, thickness, and surface area of cortical gray matter measured using structural magnetic resonance imaging at 3 scan waves.ResultsOf the 193 children, 90 had a diagnosis of major depressive disorder; 116 children had 3 full waves of neuroimaging scans. Findings demonstrated marked alterations in cortical gray matter volume loss (slope estimate, -0.93 cm³; 95% CI, -1.75 to -0.10 cm³ per scan wave) and thinning (slope estimate, -0.0044 mm; 95% CI, -0.0077 to -0.0012 mm per scan wave) associated with experiencing an episode of major depressive disorder before the first magnetic resonance imaging scan. In contrast, no significant associations were found between development of gray matter and family history of depression or experiences of traumatic or stressful life events during this period.Conclusions and relevanceThis study demonstrates an association between early childhood depression and the trajectory of cortical gray matter development in late school age and early adolescence. These findings underscore the significance of early childhood depression on alterations in neural development.

Project description:We aimed to determine if adult bone mineral density (BMD) susceptibility loci were associated with pediatric bone mass and density, and if sex and pubertal stage influenced any association. We analyzed prospective areal BMD (aBMD) and bone mineral content (BMC) data from the Bone Mineral Density in Childhood Study (n = 603, European ancestry, 54% female). Linear mixed models were used to assess if 77 single-nucleotide polymorphisms (SNPs) near known adult BMD susceptibility loci interacted with sex and pubertal stage to influence the aBMD/BMC; adjusting for age, BMI, physical activity, and dietary calcium. The strongest main association was observed between an SNP near C7orf58 and distal radius aBMD. However, this association had a significant sex • SNP interaction, revealing a significant association only in females (b = -0.32, p = 1.8 × 10(-6)). Furthermore, the C12orf23 locus had significant interactions with both sex and pubertal stage, revealing associations in females during Tanner stage I for total hip aBMD (b = 0.24, p = 0.001) and femoral neck aBMD (b = 0.27, p = 3.0 × 10(-5)). In contrast, the sex • SNP interactions for loci near LRP5 and WNT16 uncovered associations that were only in males for total body less head BMC (b = 0.22, p = 4.4 × 10(-4)) and distal radius aBMD (b = 0.27, p = 0.001), respectively. Furthermore, the LRP5 locus interacted with both sex and pubertal stage, demonstrating associations that were exclusively in males during Tanner V for total hip aBMD (b = 0.29, p = 0.003). In total, significant sex • SNP interactions were found at 15 loci; pubertal stage • SNP interactions at 23 loci and 19 loci interacted with both sex and pubertal stage. In conclusion, variants originally associated with adult BMD influence bone mass in children of European ancestry, highlighting the fact that many of these loci operate early in life. However, the direction and magnitude of associations for a large number of SNPs only became evident when accounting for sex and maturation.

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Dataset Information

Hippocampal Shape Maturation in Childhood and Adolescence.

Publications

Hippocampal Shape Maturation in Childhood and Adolescence.

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