A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.
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ABSTRACT:
SUBMITTER: Alpert A
PROVIDER: S-EPMC6686855 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.
Alpert Ayelet A Pickman Yishai Y Leipold Michael M Rosenberg-Hasson Yael Y Ji Xuhuai X Gaujoux Renaud R Rabani Hadas H Starosvetsky Elina E Kveler Ksenya K Schaffert Steven S Furman David D Caspi Oren O Rosenschein Uri U Khatri Purvesh P Dekker Cornelia L CL Maecker Holden T HT Davis Mark M MM Shen-Orr Shai S SS
Nature medicine 20190306 3
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual's immune age. Here, we use multiple 'omics' technologies to capture population- and individual-level changes in the human immune system of 135 healthy adult individuals of different ages sampled longitudinally over a nine-year period. We observed high inter-individual variability in the rates of change of cellular freque ...[more]
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