Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC6687752 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Han Xiaoqing X Shi Huifang H Sun Yingying Y Shang Chao C Luan Tao T Wang Dake D Ba Xueqing X Zeng Xianlu X
Cell death & disease 20190808 8
Myeloid-derived suppressor cells (MDSCs) comprise a critical component of the tumor environment and CXCR2 reportedly plays a key role in the pathophysiology of various inflammatory diseases. Here, CXCR2 expression on granulocyte and macrophage progenitor cells (GMPs) was found to participate in myeloid cell differentiation within the tumor environment. In CXCR2-deficient tumor-bearing mice, GMPs exhibited fewer macrophage and dendritic cell progenitor cells than wild-type tumor-bearing mice, the ...[more]