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Ni-Catalyzed Arylboration of Unactivated Alkenes: Scope and Mechanistic Studies.

ABSTRACT: A method for the Ni-catalyzed arylboration of unactivated monosubstituted, 1,1-disubstituted, and trisubstituted alkenes is disclosed. The reaction is notable in that it converts highly substituted alkenes, aryl bromides, and diboron reagents to products that contain a quaternary carbon and a synthetically versatile carbon-boron bond with control of stereoselectivity and regioselectivity. In addition, the method is demonstrated to be useful for the synthesis of saturated nitrogen heterocycles, which are important motifs in pharmaceutical compounds. Finally, due to the unusual reactivity demonstrated, the mechanistic details of the reaction were studied with both computational and experimental techniques.

SUBMITTER: Sardini SR

PROVIDER: S-EPMC6688169 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Ni-Catalyzed Arylboration of Unactivated Alkenes: Scope and Mechanistic Studies.

Sardini Stephen R SR Lambright Alison L AL Trammel Grace L GL Omer Humair M HM Liu Peng P Brown M Kevin MK

Journal of the American Chemical Society 20190604 23

A method for the Ni-catalyzed arylboration of unactivated monosubstituted, 1,1-disubstituted, and trisubstituted alkenes is disclosed. The reaction is notable in that it converts highly substituted alkenes, aryl bromides, and diboron reagents to products that contain a quaternary carbon and a synthetically versatile carbon-boron bond with control of stereoselectivity and regioselectivity. In addition, the method is demonstrated to be useful for the synthesis of saturated nitrogen heterocycles, w ...[more]

PMID: 31184148

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