Ontology highlight
ABSTRACT:
SUBMITTER: Liang J
PROVIDER: S-EPMC6689003 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Liang Jing J Zhu Jianhui J Wang Mengmeng M Singal Amit G AG Odewole Mobolaji M Kagan Sofia S Renteria Veronica V Liu Suyu S Parikh Neehar D ND Lubman David M DM
Scientific reports 20190809 1
A mass spectrometric analysis platform has been developed to determine whether glycosylation patterns of alpha-1 acid glycoprotein (AGP) could be used as a marker for early detection of hepatocellular carcinoma (HCC) in different etiologies, i.e. non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALC), and hepatitis C virus (HCV). MALDI-MS profiling of N-glycans of AGP purified from 20 μL of patient serum in HCC (n = 72) and liver cirrhosis (n = 58) showed that a unique trifucosylate ...[more]