Significant correlations between human cortical bone mineral density and quantitative susceptibility mapping (QSM) obtained with 3D Cones ultrashort echo time magnetic resonance imaging (UTE-MRI).

ABSTRACT: PURPOSE:Quantitative susceptibility mapping (QSM) MRI is a tool that can characterize changes in susceptibility, an intrinsic property which is associated with compositional changes in the tissue. Current QSM estimation of cortical bone is challenging because conventional clinical MRI cannot acquire signal in cortical bone. This study aimed to implement Cones 3D ultrashort echo time MRI (UTE-MRI) for ex vivo QSM measurements in human tibial cortical bone, investigating the correlations of QSM with volumetric intracortical bone mineral density (BMD). MATERIALS AND METHODS:Nine tibial midshaft cortical bone specimens (25?mm long specimens cut at the mid-point of tibial shaft, 67?±?20?years old, 5 women and 4 men) were scanned on a clinical 3?T MRI scanner for QSM measurement. The specimens were also scanned on a high-resolution micro-computed tomography (?CT) scanner for volumetric BMD estimation. QSM and ?CT results were compared at approximately nine regions of interest (ROIs) per specimen. RESULTS:Average 3D UTE-MRI QSM showed significantly strong correlation with volumetric BMD (R?=?-0.82, P?

SUBMITTER: Jerban S 

PROVIDER: S-EPMC6689249 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature