Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6690588 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Li Hongda H Saucedo-Cuevas Laura L Yuan Ling L Ross Danica D Johansen Anide A Sands Daniel D Stanley Valentina V Guemez-Gamboa Alicia A Gregor Anne A Evans Todd T Chen Shuibing S Tan Lei L Molina Henrik H Sheets Nicholas N Shiryaev Sergey A SA Terskikh Alexey V AV Gladfelter Amy S AS Shresta Sujan S Xu Zhiheng Z Gleeson Joseph G JG
Neuron 20190131 6
Zika virus (ZIKV) targets neural progenitor cells in the brain, attenuates cell proliferation, and leads to cell death. Here, we describe a role for the ZIKV protease NS2B-NS3 heterodimer in mediating neurotoxicity through cleavage of a host protein required for neurogenesis. Similar to ZIKV infection, NS2B-NS3 expression led to cytokinesis defects and cell death in a protease activity-dependent fashion. Among binding partners, NS2B-NS3 cleaved Septin-2, a cytoskeletal factor involved in cytokin ...[more]