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Fine-grained simulations of the microenvironment of vascularized tumours.


ABSTRACT: One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.

SUBMITTER: Fredrich T 

PROVIDER: S-EPMC6690935 | biostudies-literature |

REPOSITORIES: biostudies-literature

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