Ontology highlight
ABSTRACT:
SUBMITTER: Cesne AL
PROVIDER: S-EPMC6691522 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cesne Axel Le AL Bauer Sebastian S Demetri George D GD Han Guangyang G Dezzani Luca L Ahmad Qasim Q Blay Jean-Yves JY Judson Ian I Schöffski Patrick P Aglietta Massimo M Hohenberger Peter P Gelderblom Hans H
BMC cancer 20190813 1
<h4>Background</h4>PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between patient characteristics, prior lines of therapy, dose intensity, and dose modifications on safety and efficacy of pazopanib in aSTS.<h4>Methods</h4>PALETTE compared pazopanib with placebo in patients with aSTS (age ≥ 18 years) whose disease had progressed during or follow ...[more]