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Co-infection of vvMDV with multiple subgroups of avian leukosis viruses in indigenous chicken flocks in China.


ABSTRACT: BACKGROUND:In China, although the ALV eradication program and the MD vaccination strategy greatly reduce the disease burdens caused by the infection of ALV and MDV, the frequent emergence of novel ALV-K or vvMDV in the vaccinated chicken flock challenges the current control strategies for both diseases. RESULTS:In Guangdong Province, an indigenous chicken flock was infected with neoplastic disease. Hematoxylin-eosin staining of the tissues showed the typical characteristics of MDV and classical ALV infection. The PCR and sequencing data demonstrated that the identified MDV was clustered into a very virulent MDV strain endemic in domestic chickens in China. Moreover, subgroups ALV-A and ALV-K were efficiently recovered from two samples. The full genome sequence revealed that the ALV-K isolate was phylogenetically close to the ALV TW3593 isolate from Taiwan Province. CONCLUSIONS:A co-infection of vvMDV with multiple ALV subgroups emerged in a chicken flock with neoplastic disease in Guangdong Province. The co-infection with different subgroups of ALV with vvMDV in one chicken flock poses the risk for the emergence of novel ALVs and heavily burdens the control strategy for MDV.

SUBMITTER: Li T 

PROVIDER: S-EPMC6691527 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Co-infection of vvMDV with multiple subgroups of avian leukosis viruses in indigenous chicken flocks in China.

Li Tuofan T   Xie Jing J   Liang Guangcheng G   Ren Dan D   Sun Shu S   Lv Lu L   Xie Quan Q   Shao Hongxia H   Gao Wei W   Qin Aijian A   Ye Jianqiang J  

BMC veterinary research 20190813 1


<h4>Background</h4>In China, although the ALV eradication program and the MD vaccination strategy greatly reduce the disease burdens caused by the infection of ALV and MDV, the frequent emergence of novel ALV-K or vvMDV in the vaccinated chicken flock challenges the current control strategies for both diseases.<h4>Results</h4>In Guangdong Province, an indigenous chicken flock was infected with neoplastic disease. Hematoxylin-eosin staining of the tissues showed the typical characteristics of MDV  ...[more]

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