Ontology highlight
ABSTRACT:
SUBMITTER: Raud B
PROVIDER: S-EPMC6691976 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Raud Brenda B McGuire Peter J PJ Jones Russell G RG Sparwasser Tim T Berod Luciana L
Immunological reviews 20180501 1
CD8<sup>+</sup> T cells are key members of the adaptive immune response against infections and cancer. As we discuss in this review, these cells can present diverse metabolic requirements, which have been intensely studied during the past few years. Our current understanding suggests that aerobic glycolysis is a hallmark of activated CD8<sup>+</sup> T cells, while naive and memory (T<sub>mem</sub> ) cells often rely on oxidative phosphorylation, and thus mitochondrial metabolism is a crucial det ...[more]