Ontology highlight
ABSTRACT:
SUBMITTER: Arbore G
PROVIDER: S-EPMC6180132 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181010 1
The induction of human CD4<sup>+</sup> Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4<sup>+</sup> T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8<sup>+</sup> T cell (CTL) responses also rely on an intrinsic complement-inflammasome axis. Here we show, using CTLs from patients with CD46 deficiency or with constitutively-active NLRP3, that CD46 delivers co-stimulatory signals for optimal CTL activity by ...[more]