Ontology highlight
ABSTRACT:
SUBMITTER: Tabish AM
PROVIDER: S-EPMC6692731 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Tabish Ali M AM Arif Mohammed M Song Taejeong T Elbeck Zaher Z Becker Richard C RC Knöll Ralph R Sadayappan Sakthivel S
American journal of physiology. Heart and circulatory physiology 20190426 1
In this study, we investigated the role of DNA methylation [5-methylcytosine (5mC)] and 5-hydroxymethylcytosine (5hmC), epigenetic modifications that regulate gene activity, in dilated cardiomyopathy (DCM). A <i>MYBPC3</i> mutant mouse model of DCM was compared with wild type and used to profile genomic 5mC and 5hmC changes by Chip-seq, and gene expression levels were analyzed by RNA-seq. Both 5mC-altered genes (957) and 5hmC-altered genes (2,022) were identified in DCM hearts. Diverse gene onto ...[more]